Irinotecan hydrochloride CAS 100286-90-6 Irinotecan Hydrochloride Irinotecan Hydrochloride

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Basic Info.
  • Brand: MOSINTER 
  • Molecular Formula: C33H39ClN4O6 
  • Molecular Weight: 623.14 
  • Refractive index: 67.7 ° (C=1, H2O) 
  • Specification: CP/USP/EP 
  • Flashing point: 482°C 
  • Boiling point: 257 °C 
  • Melting point: 250-256°C (dec.) 
  • Vapour pressure: 1.31E-32mmHg at 25°C 
  • Storage condition: Refrigerator 
  • Model No.: C33H39ClN4O6 
  • Place of Origin: Sichuan  
  • Min.Order: 10 Kilogram
  • Means of Transport: Ocean, Air, Land
Supply Capacity
  • Production Capacity: 50 Ton/year
  • Packing:According to the request of customer
  • Delivery Date: within 7 days

Irinotecan hydrochloride (CAS: 100286-90-6)


Item

Index

Molecular Formula

C33H39ClN4O6

Molecular Weight

623.14

Specification

CP/USP/EP

Melting point

250-256°C (dec.)

Boiling point

257 °C

Refractive index

67.7 ° (C=1, H2O)


Irinotecan (Camptosar, Pfizer; Campto, Yakult Honsha) is a medicine used for the treatment of cancer.

Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.In chemical terms, it is a semisynthetic analogue of the natural alkaloidcamptothecin.

Its main use is in colon cancer, in particular, in combination with other chemotherapy agents. This includes the regimen FOLFIRI, which consists of infusional 5-fluorouracil, leucovorin, and irinotecan.

Irinotecan received accelerated approval by the U.S. Food and Drug Administration (FDA) in 1996 and full approval in 1998. During development, it was known as CPT-11.

Hydrochloric acid, stand for kang is a semi-synthetic water-soluble derivative of camptothecin, at room temperature for light yellow powder or light yellow crystalline powder, odourless. Slightly soluble in water, ethanol or chloroform, insoluble in acetone. Camptothecin can specifically combined with topoisomerase I, the latter induce reversible single fracture, thus make double-stranded DNA structure unwinding; Iraq made for kang and its active metabolites of SN - 38 can combine with DNA topoisomerase I - compounds, so as to prevent fracture of the single bond connection again, the resulting cell toxicity, the cytotoxicity is time dependent, and specific role in S phase, the toxicity is stronger than the set for kang. Is suitable for the treatment of advanced colorectal cancer patients, folic acid and 5 - fluorouracil and the joint treatment always did not receive chemotherapy of patients with advanced colorectal cancer, as a single medication, treatment after chemotherapy regimens including 5 - fluorouracil treatment failure in patients. Iraq made for kang in in vivo and in vitro studies have broad spectrum, strong antitumor activity, it is important to the stand for kang and its metabolites on.


Applicetion:Used for the preparation of injection; Used as anticancer medicine.


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MOSINTER GROUP LIMITED
Guangbo Center Office 2001, YinXianDaDao 1357, Ningbo, Zhejiang, China (Mainland) / 315100
Fax: +86-574-89212215
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