91-22-5 Benzopyridine Medical Intermediate C9H7N , Quinoline , Benzo Pyridine For Pharmaceutical Industry
Quick Detail:
A colorless liquid. With alcohol, ether and carbon disulfide miscible, soluble in water, insoluble in cold water. With moisture absorption, can absorb moisture from the air, and water content of 22%, with the steam can be volatile.
Description:
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Molecular formula: Molecular Weight: |
C9H7N 129.16 |
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CAS: |
91-22-5 |
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melting point: |
-15.6 |
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boiling point: |
238.05,114(2.27kPa) |
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density ratio: |
1.0929(20/4) |
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refractive index: |
1.62683 |
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flash(ing) point: |
101 |
Chemical property
Quinoline structure
In case of fire, high heat combustible. With the oxidant react. Thermal decomposition of nitric oxide release toxic smoke. Combustion produces carbon dioxide, carbon monoxide, decomposed products of nitric oxide.
The preparation method
Quinoline can be extracted from coal tar washing oil or naphthalene oil. Fraction of naphthalene oil and wash oil fraction using dilute sulfuric acid washing, get quinoline sulfate based solution, the removal of neutral oil and impurity with steam, and then alkali or ammonia decomposition. The separated crude quinoline and its homologues by dehydration with high yield, distillation tower distillation, cut the boiling segment is 237.5-239.5 fraction can be obtained, crude quinoline containing quinoline, isoquinoline 15% 83%. The crude quinoline concentration of phosphoric acid water solution 60%, cooling and filtering, to obtain the quinoline phosphate crystal. Alkali decomposed, the purity of the product is 90%-92%. Repeated treatment with phosphoric acid, recrystallization, the purity of 98%-99% can be quinoline. Synthesis of quinoline most representative method is the intrinsic Luopu synthesis: with aniline, glycerol, sulfuric acid and oxidizing agents (such as nitrobenzene) together with heating, via dehydrocyclization and generation of quinoline.
Security terminology
S26: in case of contact with eyes, rinse immediately with plenty of water and seek medical advice. (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.)
S36: wear suitable protective clothing. (Wear suitable protective clothing.)
S337: wear suitable gloves. (Wear suitable gloves.)
S369: goggles and masks. (Wear eye / face protection.)
Applications:
1, quinoline for preparation of nicotinic acid and hydroxyl quinoline drugs, phthalocyanine blue pigment and photosensitive pigment, rubber accelerator and pesticide 8- hydroxy - quinoline ketone etc.. The rats treated with LD50 for 460mg/kg.
2, used as a reagent in organic synthesis, alkaline condensation agent and solvent.
3, used as an analytical reagent, solvent, also used for the separation of vanadate and arsenate.
4, making the arm, also can be used in acid, solvent, antiseptic; for the production of nicotinic acid and 8- hydroxyquinoline drug pharmaceutical industry; for the production of phthalocyanine blue pigment and photosensitive pigment printing and dyeing industry; used in making accelerator rubber industry; agriculture for the production of 8- hydroxy - quinoline ketone and other pesticides.
Specifications:
Quinoline
CAS No.: 91-22-5
Kinds of purity
Competitive price and good quality
Free samples are available
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