Buy Raloxifene HCl Bulk Steroid Powder Raloxifene hydrochloride Raw Source

Price: 1.0 USD
Trade Term: FOB,CFR,CIF
Payment Terms: T/T,WU,Money Gram
skype
Trade on HiSupplier, Worry Free Guarantee
Trading safety, secure your money, lower the risk, protect both buyers and suppliers
HiSupplier is a Chinese multinational company in U.S, it helps to coordination and order landing.
More ›
  • Product Details
  • Company Profile
  • Product Reviews
Basic Info.
  • Brand Name: Yijing 
  • CAS No.: 82640-04-8 
  • Purity: 99% 
  • Molecular Formula: C17h19n5 
  • Molecular Weight: 293.37 
  • Storage: Shading, confined preservation 
  • Certification: GMP, HSE, ISO 9001, USP, BP 
  • Shipment:: EMS, DHL, FedEx, TNT 
  • Reship Policy: About 60% reship 
  • Delivery Time: Within 24 hours 
  • Leading Time: About 5~8 working days 
  • Skype: histeroids 
  • Grade: Pharmaceutical Grade 
  • Model No.: 82640-04-8 
  • Place of Origin: Shanghai  
  • Min.Order: 100 Gram
  • Means of Transport: Express, Air
Supply Capacity
  • Production Capacity: 500kg/month
  • Packing:Discreet packages
  • Delivery Date: About 4~8 working days

Skype: histeroids

Whatsapp:+86 18121080540


Anti-Estrogen Steroids Raloxifene hydrochloride Powder For Treating Breast Cancer 

Raloxifene Hydrochloride/Raloxifene HCl 82640-04-8

 

Raloxifene hydrochloride Description:

Raloxifene hydrochloride is a second-generation Selective Estrogen Receptor Modulator (SERM) of the benzothiophene family. This drug is similar in effect to tamoxifen, exhibiting estrogen receptor antagonist (blocking) properties in some tissues while acting as an estrogen receptor agonist (activator) in others.

 

The main point of variation between these two agents is their tissue selectivity. While raloxifene hydrochloride is a strong anti-estrogen in breast and uterine tissues, it appears to be estrogenic in bone. This allows it to protect bone density, mimicking the beneficial effects of endogenous estradiol. This is quite different from tamoxifen, which is anti-estrogenic in both breast and bone.

 

In a role that was novel for an anti-estrogen, raloxifene hydrochloride was approved by the FDA for the prevention and treatment of osteoporosis in post-menopausal women. It is also being investigated for several other potential uses, including the treatment and prevention of cardiovascular disease, breast cancer, gynecomastia, prostate cancer, acromegaly, and uterine cancer.

 

Raloxifene hydrochloride Mechanism of Action:

Evista (raloxifene hydrochloride) is an estrogen agonist/antagonist, referred to as a selective estrogen receptor modulator (SERM) and belongs to the benzothiophene class of compounds. The biological actions of raloxifene are largely mediated through binding to estrogen receptors.

 

This binding results in activation of estrogenic pathways in some tissues (agonism) and and the blockade of estrogenic pathways in other tissues (antagonism). The agonistic or antagonistic activity of raloxiffene depends on the extent of recruitment of coactivators and corepressors to estrogen receptor (ER) target gene promotors.

 

Raloxifene appears to act as an estrogen agonist in bone. It decreases bone resorption and bone turnover, increases bone mineral density and decreases fracture incidence.

 

Raloxifene hydrochloride Administration:

Raloxifene hydrochloride is FDA approved for the treatment and prevention of osteoporosis in postmenopausal women, reducing the risk of invasive breast cancer in postmenopausal women with osteoporosis, and reducing the risk of invasive breast cancer in postmenopausal women at high risk for invasive breast cancer.

 

The recommended dose is one 60 mg tablet administered once per day, without regard to meals. When used (off-label) to mitigate the estrogenic side effects of anabolic/androgenic steroid use, male athletes and bodybuilders often take 30 mg to 60 mg per day.



Send message to this supplier
Ms. Leslie@pharm-china.com (Sales Manager)
Tel: 86-181-21080540
Mobile: +86-18121080540
Enter between 20 to 3,000 chatacters.
Contact Method
Shanghai Yijing Pharmaceutical&Chemical Co.,Ltd
Pudong New Area, Shanghai, China (Mainland) / 201204
Fax: 86-181-21080540
Didn't find what you're looking for? Post Buying Lead or contact our customer service specialist for help!
Buyer Help Center