Nisoldipine CAS 63675-72-9 Baymycard Syscor ZADIPINA

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Basic Info.
  • Brand: MOSINTER 
  • CAS: 63675-72-9 
  • Molecular Formula: C20H24N2O6 
  • Appearance: Appearance Yellow crystalline powder 
  • Specification: CP/USP/EP 
  • Melting point: 388.42°C 
  • Molecular Weight: 388.42 
  • Model No.: C20H24N2O6 
  • Place of Origin: Sichuan  
  • Min.Order: 10 Kilogram
  • Means of Transport: Ocean, Air, Land
Supply Capacity
  • Production Capacity: 33T/Year
  • Packing:According to the customer request
  • Delivery Date: within 7 days

Nisoldipine (CAS: 63675-72-9)


Item

Index

Molecular Formula

C20H24N2O6

Molecular Weight

388.42

Specification

CP/USP/EP

Appearance

Yellow crystalline powder

Melting point

148-152°C

Nisoldipine (INN) is a calcium channel blocker of the dihydropyridine class. It sold in the United Statesunder the proprietary name Sular. Nisoldipine has tropism for cardiac blood vessels. 


External links

  • DDB 30009

  • Mielcarek J, Grobelny P, Szamburska O (2005). "The effect of beta-carotene on the photostability of nisoldipine.". Methods Find Exp Clin Pharmacol 27 (3): 167–71. doi:10.1358/mf.2005.27.3.890873.PMID 15834448.

  • Missan S, Zhabyeyev P, Dyachok O, Jones SE, McDonald TF (November 2003). "Block of cardiac delayed-rectifier and inward-rectifier K+ currents by nisoldipine". Br. J. Pharmacol. 140 (5): 863–70.doi:10.1038/sj.bjp.0705518. PMC 1574108. PMID 14530219.

  • Hamilton S, Houle L, Thadani U (1999). "Rapid-release and coat-core formulations of nisoldipine in treatment of hypertension, angina, and heart failure.". Heart Dis 1 (5): 279–88. PMID 1172063

Pharmacologic action

The product is made of two hydrogen pyridine class calcium antagonists can prevent myocardial and vascular smooth muscle of calcium intake, selective dilating coronary artery and peripheral vascular function, improve the myocardial blood flow, reduce the peripheral resistance, reducing myocardial oxygen consumption, enhance myocardial hypoxia tolerance, reduce high blood pressure patients blood pressure.

Antihypertensive effect was dose dependent. The fall in blood pressure at the same time, the breath and does not affect the central nervous system.

Application

Treatment of mild and moderate hypertension


Usage and dosage: Oral medication, the adult 5-10 mg each time, 2 times a day, once in the morning and night

Adverse reactions: Sometimes a mild, transient palpitations, red face, dizziness, tinnitus, fatigue, nausea, rashes, etc.

Forbidden disease: Pregnant women Allergies are prohibited

Considerations

The driver, the work high above the antihypertensive treatment, and precision instrument operators should not use this product.

Excessive lowering of blood pressure, severe liver function is impaired and elderly patients should be careful.

Withdrawal should be gradually reduced.

Lactating women such as taking, should first stop breastfeeding






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MOSINTER GROUP LIMITED
Guangbo Center Office 2001, YinXianDaDao 1357, Ningbo, Zhejiang, China (Mainland) / 315100
Fax: +86-574-89212215
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