2mg Peptide Hormones Bodybuilding MGF Powder 100 % Delivery Free Samples

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2mg MGF Mechano Growth Factor 100% Delivery Free Samples MGF Powder

 

 

Product name MGF, Mechano Growth Factor
Specification 2mg/vial
Appearance White powder
Form & Formulations Sterile Filtered white lyophilized (Freeze-Dried)
Purity >98% by RP-HPLC
Water Content ≤ 7.0% by Karl Fischer
Acetate Content ≤ 10.0% by RP-HPLC
Bacterial Endotoxins ≤ 5EU/mg
Storage 2-8 degree centigrade refrigerator
Pacakge 1kit=10vials Alumnium foil+bubble+carton

 

The physiological role of MGF has been well studied on the cellular model in vitro and in mice. In contrast to IGF-1 growth factor causes mechanical mainly division dormant muscle cells by activation of different receptors. Reduced synthesis MGF - this is the main reason that results in the reduction of muscle mass in dystrophic patients and the elderly.

 

Mechano growth factor (MGF) is a novel splice variant of the Insulin-Like Growth Factor-1 (IGF-1), also known as IGF-1 Ec in humans and IGF-1Eb in rodents. It is actually originally called MGF because the RNA form of it is expressed in muscle tissues in response to the overload or/and damage of muscle growth tissue. The C-terminal peptide of the mechano growth factor (MGF) is a crucial region for the alternative splicing of the peptide. The alternative splicing in the MGF is brought about by the shift in the reading frame in which a specific C-terminal sequence (E-domain) is encoded by exon 5 and the first part of the exon 6. Another interesting point in MGF is that, because of the E domain it contains, MGF can act on muscles independently from the rest of the molecule. Furthermore, MGF can elicit very different effects with mGF promoting satellite cells proliferation and IGF-1 inducing differentiation (Dluzniewska et al. 2005).

Age Related Muscle Loss and MGF

MGF was suggested to play a number of physiological roles because the failure in its expression may result to age-related loss of skeletal function. Included in its functions is its ability to become a potent neuroprotective as supported by the study that has shown functional copies of the MGF cDNA to be expressed in a plasmid vector which then protected facial neurons after nerve damage (Dluzniewska et al. 2005). One such failure is called sarcopenia. It would also appear that with regards to age, the young have a better ability to respond to MGF (4), and that the elderly experience a decreased response to MGF which results in a decreased ability to stimulate the growth of new muscle tissue.


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